Expression of ALCAM in cancer - Summary - The Human Protein Atlas

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ALCAM

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ALCAM
Gene description	Activated leukocyte cell adhesion molecule
Protein class	Cancer-related genes CD markers Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-138 MG)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most tissues, including parathyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 2 antibodies. HPA010926 , CAB002148
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010926	CAB002148

GENE INFORMATION
Gene name	ALCAM (HGNC Symbol)
Synonyms	CD166, MEMD
Description	Activated leukocyte cell adhesion molecule (HGNC Symbol)
Entrez gene summary	This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
Chromosome	3
Cytoband	q13.11
Chromosome location (bp)	105366909 - 105576900
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170017 (version 83.38)
Entrez gene	214
UniProt	Q13740 (UniProt - Evidence at protein level)
neXtProt	NX_Q13740
Antibodypedia	ALCAM antibodies

PROTEIN BROWSER

ALCAM-001	ALCAM-002	ALCAM-005	ALCAM-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALCAM-001 ENSP00000305988 ENST00000306107	Q13740 [Direct mapping] CD166 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0008045 [motor neuron axon guidance] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0030424 [axon] GO:0043025 [neuronal cell body] GO:0070062 [extracellular exosome] Show all	583 aa 65.1 kDa	Yes	1
ALCAM-002 ENSP00000419236 ENST00000472644	Q13740 [Direct mapping] CD166 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	570 aa 63.7 kDa	Yes	1
ALCAM-005 ENSP00000418213 ENST00000486979	F5GXJ9 [Direct mapping] CD166 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	532 aa 59.5 kDa	No	1
ALCAM-007 ENSP00000418937 ENST00000465413	H7C543 [Direct mapping] CD166 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	344 aa 38.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.