Expression of CNGB3 in cancer - Summary - The Human Protein Atlas

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CNGB3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNGB3
Gene description	Cyclic nucleotide gated channel beta 3
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (SCLC-21H)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in basal membrane in photoreceptor layer in retina.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Approved based on 1 antibody. HPA057244
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057244

GENE INFORMATION
Gene name	CNGB3 (HGNC Symbol)
Synonyms	ACHM1, ACHM3, RMCH
Description	Cyclic nucleotide gated channel beta 3 (HGNC Symbol)
Entrez gene summary	This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]
Chromosome	8
Cytoband	q21.3
Chromosome location (bp)	86553977 - 86743675
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170289 (version 83.38)
Entrez gene	54714
UniProt	Q9NQW8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQW8
Antibodypedia	CNGB3 antibodies

PROTEIN BROWSER

CNGB3-001	CNGB3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNGB3-001 ENSP00000316605 ENST00000320005	Q9NQW8 [Direct mapping] Cyclic nucleotide-gated cation channel beta-3 Show all	Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001750 [photoreceptor outer segment] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005223 [intracellular cGMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006812 [cation transport] GO:0007165 [signal transduction] GO:0007601 [visual perception] GO:0030553 [cGMP binding] GO:0042391 [regulation of membrane potential] GO:0071805 [potassium ion transmembrane transport] GO:1902495 [transmembrane transporter complex] Show all	809 aa 92.2 kDa	No	5
CNGB3-003 ENSP00000428329 ENST00000517327	H0YAZ4 [Direct mapping] Cyclic nucleotide-gated cation channel beta-3 Show all	Predicted intracellular proteins Show all	GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005887 [integral component of plasma membrane] GO:0042391 [regulation of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	111 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.