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TMED10

GENERAL INFORMATION

Gene name

 TMED10

Gene description

 Transmembrane p24 trafficking protein 10

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 4 antibodies.
HPA047139 , HPA050539 , CAB034442 , CAB037251
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA047139
HPA050539
CAB034442
CAB037251

GENE INFORMATION

Gene name

 TMED10 (HGNC Symbol)

Synonyms

 p23, P24(DELTA), p24d1, p24delta1, TMP21

Description

 Transmembrane p24 trafficking protein 10 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 75131470 - 75176631

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170348 (version 83.38)

Entrez gene

 10972

UniProt

 P49755 (UniProt - Evidence at protein level)

neXtProt

 NX_P49755

Antibodypedia

 TMED10 antibodies

PROTEIN BROWSER
TMED10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TMED10-001
ENSP00000303145
ENST00000303575
P49755 [Direct mapping]
Transmembrane emp24 domain-containing protein 10
A0A024R6I3 [Target identity:100%; Query identity:100%]
Transmembrane emp24-like trafficking protein 10 (Yeast), isoform CRA_a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005794 [Golgi apparatus]
GO:0005801 [cis-Golgi network]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0007030 [Golgi organization]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019905 [syntaxin binding]
GO:0030137 [COPI-coated vesicle]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030667 [secretory granule membrane]
GO:0032403 [protein complex binding]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0035459 [cargo loading into vesicle]
GO:0035964 [COPI-coated vesicle budding]
GO:0042470 [melanosome]
GO:0042589 [zymogen granule membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043279 [response to alkaloid]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045055 [regulated secretory pathway]
GO:0048199 [vesicle targeting, to, from or within Golgi]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0048208 [COPII vesicle coating]
GO:0051259 [protein oligomerization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070765 [gamma-secretase complex]
GO:1902003 [regulation of beta-amyloid formation]
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 219 aa
25 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.