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EMX2

GENERAL INFORMATION

Gene name

 EMX2

Gene description

 Empty spiracles homeobox 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cervix, uterine, endometrium, epididymis, fallopian tube, kidney, seminal vesicle, smooth muscle)
GTEx:Tissue enhanced (endometrium, fallopian tube)
FANTOM5:Tissue enhanced (seminal vesicle)

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 1 antibody.
HPA065294
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, endometrium, epididymis, fallopian tube, kidney, seminal vesicle, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium, fallopian tube)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle)

GENE INFORMATION

Gene name

 EMX2

Synonyms

Description

 Empty spiracles homeobox 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]

Chromosome

 10

Cytoband

 q26.11

Chromosome location (bp)

 117542444 - 117549546

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170370 (version 83.38)

Entrez gene

 2018

UniProt

 Q04743 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04743

Antibodypedia

 EMX2 antibodies

PROTEIN BROWSER
EMX2-001
EMX2-002
EMX2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EMX2-001
ENSP00000450962
ENST00000553456
Q04743 [Direct mapping]
Homeobox protein EMX2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
GO:0009952 [anterior/posterior pattern specification]
GO:0010468 [regulation of gene expression]
GO:0021542 [dentate gyrus development]
GO:0021796 [cerebral cortex regionalization]
GO:0021846 [cell proliferation in forebrain]
GO:0021885 [forebrain cell migration]
GO:0021987 [cerebral cortex development]
GO:0030182 [neuron differentiation]
GO:0030900 [forebrain development]
GO:0042493 [response to drug]
GO:0043565 [sequence-specific DNA binding]
GO:0072001 [renal system development]
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 252 aa
28.3 kDa 		No 0
EMX2-002
ENSP00000480271
ENST00000616794
A0A087WWJ6 [Direct mapping]
Homeobox protein EMX2
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Predicted intracellular proteins
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 69 aa
8.1 kDa 		No 0
EMX2-201
ENSP00000474874
ENST00000442245
Q04743 [Direct mapping]
Homeobox protein EMX2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 169 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.