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HARS

GENERAL INFORMATION

Gene name

 HARS

Gene description

 Histidyl-tRNA synthetase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036539
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036539

GENE INFORMATION

Gene name

 HARS

Synonyms

Description

 Histidyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 5

Cytoband

 q31.3

Chromosome location (bp)

 140673173 - 140692024

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170445 (version 83.38)

Entrez gene

 3035

UniProt

 P12081 (UniProt - Evidence at protein level)

neXtProt

 NX_P12081

Antibodypedia

 HARS antibodies

PROTEIN BROWSER
HARS-001
HARS-003
HARS-005
HARS-006
HARS-008
HARS-009
HARS-011
HARS-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HARS-001
ENSP00000425634
ENST00000504156
P12081 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0032543 [mitochondrial translation]
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 509 aa
57.4 kDa 		No 0
HARS-003
ENSP00000430063
ENST00000504366
B3KWE1 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic; Histidyl-tRNA synthetase, isoform CRA_a; cDNA FLJ42841 fis, clone BRCOC2003213, highly similar to Histidyl-tRNA synthetase (EC 6.1.1.21)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0032543 [mitochondrial translation]
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 440 aa
49.6 kDa 		No 0
HARS-005
ENSP00000393244
ENST00000431330
B4E1C5 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic; cDNA FLJ58562, highly similar to Histidyl-tRNA synthetase (EC 6.1.1.21)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0032543 [mitochondrial translation]
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 395 aa
43.9 kDa 		No 0
HARS-006
ENSP00000425889
ENST00000507746
E7ETE2 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0032543 [mitochondrial translation]
Show all
 288 aa
31.9 kDa 		No 0
HARS-008
ENSP00000304668
ENST00000307633
P12081 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0032543 [mitochondrial translation]
Show all
 449 aa
50.2 kDa 		No 0
HARS-009
ENSP00000387893
ENST00000457527
P12081 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0032543 [mitochondrial translation]
Show all
 489 aa
54.8 kDa 		No 0
HARS-011
ENSP00000411085
ENST00000415192
B4DDD8 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic; cDNA FLJ53703, highly similar to Histidyl-tRNA synthetase (EC 6.1.1.21)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0032543 [mitochondrial translation]
Show all
 435 aa
48.6 kDa 		No 0
HARS-012
ENSP00000411511
ENST00000438307
P12081 [Direct mapping]
Histidine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004821 [histidine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006427 [histidyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0032543 [mitochondrial translation]
Show all
 469 aa
52.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.