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CD14

GENERAL INFORMATION

Gene name

 CD14

Gene description

 CD14 molecule

Protein class

 Cancer-related genes
CD markers
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, CACO-2, SiHa)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 5 antibodies.
HPA001887 , HPA002127 , CAB033631 , CAB072865 , CAB072866
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA001887
HPA002127
CAB033631
CAB072865
CAB072866

GENE INFORMATION

Gene name

 CD14

Synonyms

Description

 CD14 molecule (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

Chromosome

 5

Cytoband

 q31.3

Chromosome location (bp)

 140631728 - 140633701

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170458 (version 83.38)

Entrez gene

 929

UniProt

 P08571 (UniProt - Evidence at protein level)

neXtProt

 NX_P08571

Antibodypedia

 CD14 antibodies

PROTEIN BROWSER
CD14-001
CD14-002
CD14-003
CD14-004
CD14-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD14-001
ENSP00000304236
ENST00000302014
P08571 [Direct mapping]
Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form
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CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001847 [opsonin receptor activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002237 [response to molecule of bacterial origin]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0009408 [response to heat]
GO:0009617 [response to bacterium]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0012501 [programmed cell death]
GO:0016019 [peptidoglycan receptor activity]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032026 [response to magnesium ion]
GO:0032481 [positive regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0045807 [positive regulation of endocytosis]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0050715 [positive regulation of cytokine secretion]
GO:0051602 [response to electrical stimulus]
GO:0070062 [extracellular exosome]
GO:0070891 [lipoteichoic acid binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 375 aa
40.1 kDa 		Yes 0
CD14-002
ENSP00000425447
ENST00000512545
D6RD81 [Direct mapping]
Monocyte differentiation antigen CD14
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 55 aa
6.2 kDa 		Yes 0
CD14-003
ENSP00000426543
ENST00000498971
D6RFL4 [Direct mapping]
Monocyte differentiation antigen CD14
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 213 aa
23.3 kDa 		Yes 0
CD14-004
ENSP00000430884
ENST00000519715
E7EVL5 [Direct mapping]
Monocyte differentiation antigen CD14
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 81 aa
9 kDa 		Yes 0
CD14-201
ENSP00000385519
ENST00000401743
P08571 [Direct mapping]
Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001847 [opsonin receptor activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0010008 [endosome membrane]
GO:0012501 [programmed cell death]
GO:0016019 [peptidoglycan receptor activity]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0070062 [extracellular exosome]
GO:0070891 [lipoteichoic acid binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
 375 aa
40.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.