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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CD14
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CD14

Gene description

CD14 molecule

Protein class

Cancer-related genes
CD markers
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Selective expression in subsets of immune cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 5 antibodies.
HPA001887 , HPA002127 , CAB033631 , CAB072865 , CAB072866
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CD14

Synonyms

Description

CD14 molecule (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

140631728 - 140633701

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170458 (version 83.38)

Entrez gene

929

UniProt

P08571 (UniProt - Evidence at protein level)

neXtProt

NX_P08571

Antibodypedia

CD14 antibodies

PROTEIN BROWSER

CD14-001
CD14-002
CD14-003
CD14-004
CD14-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD14-001
ENSP00000304236
ENST00000302014
P08571 [Direct mapping]
Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001847 [opsonin receptor activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002237 [response to molecule of bacterial origin]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0009408 [response to heat]
GO:0009617 [response to bacterium]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0012501 [programmed cell death]
GO:0016019 [peptidoglycan receptor activity]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032026 [response to magnesium ion]
GO:0032481 [positive regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0045807 [positive regulation of endocytosis]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0050715 [positive regulation of cytokine secretion]
GO:0051602 [response to electrical stimulus]
GO:0070062 [extracellular exosome]
GO:0070891 [lipoteichoic acid binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
375 aa
40.1 kDa
Yes 0
CD14-002
ENSP00000425447
ENST00000512545
D6RD81 [Direct mapping]
Monocyte differentiation antigen CD14
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
55 aa
6.2 kDa
Yes 0
CD14-003
ENSP00000426543
ENST00000498971
D6RFL4 [Direct mapping]
Monocyte differentiation antigen CD14
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
213 aa
23.3 kDa
Yes 0
CD14-004
ENSP00000430884
ENST00000519715
E7EVL5 [Direct mapping]
Monocyte differentiation antigen CD14
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
81 aa
9 kDa
Yes 0
CD14-201
ENSP00000385519
ENST00000401743
P08571 [Direct mapping]
Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0001847 [opsonin receptor activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0010008 [endosome membrane]
GO:0012501 [programmed cell death]
GO:0016019 [peptidoglycan receptor activity]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0046696 [lipopolysaccharide receptor complex]
GO:0070062 [extracellular exosome]
GO:0070891 [lipoteichoic acid binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071223 [cellular response to lipoteichoic acid]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
375 aa
40.1 kDa
Yes 0

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