Expression of KRT6C in cancer - Summary - The Human Protein Atlas

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KRT6C

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT6C
Gene description	Keratin 6C, type II
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enriched (RPMI-8226)
HPA (normal tissue):	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in squamous and respiratory epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA045697 , HPA061168
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045697	HPA061168

GENE INFORMATION
Gene name	KRT6C (HGNC Symbol)
Synonyms	KRT6E
Description	Keratin 6C, type II (HGNC Symbol)
Entrez gene summary	Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52468516 - 52473785
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170465 (version 83.38)
Entrez gene	286887
UniProt	P48668 (UniProt - Evidence at protein level)
neXtProt	NX_P48668
Antibodypedia	KRT6C antibodies

PROTEIN BROWSER

KRT6C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT6C-001 ENSP00000252250 ENST00000252250	P48668 [Direct mapping] Keratin, type II cytoskeletal 6C Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0045095 [keratin filament] GO:0045104 [intermediate filament cytoskeleton organization] GO:0070062 [extracellular exosome] Show all	564 aa 60 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.