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KRT6C

GENERAL INFORMATION

Gene name

 KRT6C

Gene description

 Keratin 6C, type II

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (esophagus)
GTEx:Group enriched (cervix, uterine, esophagus, vagina)
FANTOM5:Group enriched (cervix, uterine, esophagus)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in squamous and respiratory epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA045697 , HPA061168
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus)

GENE INFORMATION

Gene name

 KRT6C (HGNC Symbol)

Synonyms

 KRT6E

Description

 Keratin 6C, type II (HGNC Symbol)

Entrez gene summary

 Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52468516 - 52473785

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170465 (version 83.38)

Entrez gene

 286887

UniProt

 P48668 (UniProt - Evidence at protein level)

neXtProt

 NX_P48668

Antibodypedia

 KRT6C antibodies

PROTEIN BROWSER
KRT6C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT6C-001
ENSP00000252250
ENST00000252250
P48668 [Direct mapping]
Keratin, type II cytoskeletal 6C
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0070062 [extracellular exosome]
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 564 aa
60 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.