Cell atlas - IRX2 - The Human Protein Atlas

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IRX2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IRX2
Gene description	Iroquois homeobox 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Cell line enhanced (AF22, BEWO, hTCEpi)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050895
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, BEWO, hTCEpi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050895	MCF7	Nucleus
	HPA050895	MCF7	Nucleoli

GENE INFORMATION
Gene name	IRX2
Synonyms
Description	Iroquois homeobox 2 (HGNC Symbol)
Entrez gene summary	IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	2745845 - 2751662
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170561 (version 83.38)
Entrez gene	153572
UniProt	Q9BZI1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZI1
Antibodypedia	IRX2 antibodies

PROTEIN BROWSER

IRX2-001	IRX2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRX2-001 ENSP00000372056 ENST00000382611	Q9BZI1 [Direct mapping] Iroquois-class homeodomain protein IRX-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001656 [metanephros development] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0072086 [specification of loop of Henle identity] GO:0072272 [proximal/distal pattern formation involved in metanephric nephron development] Show all	471 aa 49.1 kDa	No	0
IRX2-002 ENSP00000307006 ENST00000302057	Q9BZI1 [Direct mapping] Iroquois-class homeodomain protein IRX-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	471 aa 49.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.