Expression of IRX2 in cancer - Summary - The Human Protein Atlas

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IRX2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IRX2
Gene description	Iroquois homeobox 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, BEWO, hTCEpi)
HPA (normal tissue):	Tissue enhanced (breast, lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membrane expression in several tissues, including breast.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA054669
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054669

GENE INFORMATION
Gene name	IRX2
Synonyms
Description	Iroquois homeobox 2 (HGNC Symbol)
Entrez gene summary	IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	2745845 - 2751662
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170561 (version 83.38)
Entrez gene	153572
UniProt	Q9BZI1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZI1
Antibodypedia	IRX2 antibodies

PROTEIN BROWSER

IRX2-001	IRX2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRX2-001 ENSP00000372056 ENST00000382611	Q9BZI1 [Direct mapping] Iroquois-class homeodomain protein IRX-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001656 [metanephros development] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0072086 [specification of loop of Henle identity] GO:0072272 [proximal/distal pattern formation involved in metanephric nephron development] Show all	471 aa 49.1 kDa	No	0
IRX2-002 ENSP00000307006 ENST00000302057	Q9BZI1 [Direct mapping] Iroquois-class homeodomain protein IRX-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	471 aa 49.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.