Cancer tissues generally showed moderate nuclear immunoreactivity frequently combined with cytoplasmic positivity. Fractions of hepatocellular carcinomas, gliomas and melanomas were strongly stained. Several carcinoids, breast, prostate and renal cancers were weakly stained or negative.
Acylphosphatase 2, muscle type (HGNC Symbol)
Entrez gene summary
Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. [provided by RefSeq, Jul 2008]