Expression of ACYP2 in cancer - Summary - The Human Protein Atlas

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ACYP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACYP2
Gene description	Acylphosphatase 2, muscle type
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA data suggest expression in most tissues, including muscle tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA035301
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035301

GENE INFORMATION
Gene name	ACYP2
Synonyms
Description	Acylphosphatase 2, muscle type (HGNC Symbol)
Entrez gene summary	Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p16.2
Chromosome location (bp)	53970838 - 54305300
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170634 (version 83.38)
Entrez gene	98
UniProt	P14621 (UniProt - Evidence at protein level)
neXtProt	NX_P14621
Antibodypedia	ACYP2 antibodies

PROTEIN BROWSER

ACYP2-001	ACYP2-002	ACYP2-003	ACYP2-006	ACYP2-007	ACYP2-008	ACYP2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACYP2-001 ENSP00000378161 ENST00000394666	P14621 [Direct mapping] Acylphosphatase-2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006796 [phosphate-containing compound metabolic process] Show all	99 aa 11.1 kDa	No	0
ACYP2-002 ENSP00000306448 ENST00000303536	F8WA34 [Direct mapping] Acylphosphatase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0008152 [metabolic process] Show all	98 aa 10.3 kDa	Yes	0
ACYP2-003 ENSP00000385674 ENST00000406041	E9PF46 [Direct mapping] Acylphosphatase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0008152 [metabolic process] Show all	97 aa 10.3 kDa	Yes	0
ACYP2-006 ENSP00000475986 ENST00000607452	U3KQL2 [Direct mapping] Acylphosphatase-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0008152 [metabolic process] Show all	172 aa 19.6 kDa	No	0
ACYP2-007 ENSP00000475658 ENST00000422521	U3KQ94 [Direct mapping] Acylphosphatase-2; HCG2040114, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.3 kDa	No	0
ACYP2-008 ENSP00000475424 ENST00000606082	U3KQ09 [Direct mapping] Acylphosphatase-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.8 kDa	No	0
ACYP2-010 ENSP00000475333 ENST00000606865	U3KPX8 [Direct mapping] Acylphosphatase-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003998 [acylphosphatase activity] GO:0008152 [metabolic process] Show all	83 aa 9.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.