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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACYP2
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACYP2

Gene description

Acylphosphatase 2, muscle type

Protein class

Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA data suggest expression in most tissues, including muscle tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA035301
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA035301

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues generally showed moderate nuclear immunoreactivity frequently combined with cytoplasmic positivity. Fractions of hepatocellular carcinomas, gliomas and melanomas were strongly stained. Several carcinoids, breast, prostate and renal cancers were weakly stained or negative.

GENE INFORMATION

Gene name

ACYP2

Synonyms

Description

Acylphosphatase 2, muscle type (HGNC Symbol)

Entrez gene summary

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p16.2

Chromosome location (bp)

53970838 - 54305300

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170634 (version 83.38)

Entrez gene

98

UniProt

P14621 (UniProt - Evidence at protein level)

neXtProt

NX_P14621

Antibodypedia

ACYP2 antibodies

PROTEIN BROWSER

ACYP2-001
ACYP2-002
ACYP2-003
ACYP2-006
ACYP2-007
ACYP2-008
ACYP2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACYP2-001
ENSP00000378161
ENST00000394666
P14621 [Direct mapping]
Acylphosphatase-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003998 [acylphosphatase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006796 [phosphate-containing compound metabolic process]
Show all
99 aa
11.1 kDa
No 0
ACYP2-002
ENSP00000306448
ENST00000303536
F8WA34 [Direct mapping]
Acylphosphatase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003998 [acylphosphatase activity]
GO:0008152 [metabolic process]
Show all
98 aa
10.3 kDa
Yes 0
ACYP2-003
ENSP00000385674
ENST00000406041
E9PF46 [Direct mapping]
Acylphosphatase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003998 [acylphosphatase activity]
GO:0008152 [metabolic process]
Show all
97 aa
10.3 kDa
Yes 0
ACYP2-006
ENSP00000475986
ENST00000607452
U3KQL2 [Direct mapping]
Acylphosphatase-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003998 [acylphosphatase activity]
GO:0008152 [metabolic process]
Show all
172 aa
19.6 kDa
No 0
ACYP2-007
ENSP00000475658
ENST00000422521
U3KQ94 [Direct mapping]
Acylphosphatase-2; HCG2040114, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
116 aa
13.3 kDa
No 0
ACYP2-008
ENSP00000475424
ENST00000606082
U3KQ09 [Direct mapping]
Acylphosphatase-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
40 aa
4.8 kDa
No 0
ACYP2-010
ENSP00000475333
ENST00000606865
U3KPX8 [Direct mapping]
Acylphosphatase-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003998 [acylphosphatase activity]
GO:0008152 [metabolic process]
Show all
83 aa
9.3 kDa
No 0

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The Human Protein Atlas project is funded
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