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ATF7

GENERAL INFORMATION

Gene name

 ATF7

Gene description

 Activating transcription factor 7

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

 Intracellular,Membrane

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several different tissue types, including cells in stroma.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003384
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA003384

GENE INFORMATION

Gene name

 ATF7 (HGNC Symbol)

Synonyms

 ATFA

Description

 Activating transcription factor 7 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 53507856 - 53626410

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170653 (version 83.38)

Entrez gene

 11016

UniProt

 P17544 (UniProt - Evidence at protein level)

neXtProt

 NX_P17544

Antibodypedia

 ATF7 antibodies

PROTEIN BROWSER
ATF7-001
ATF7-002
ATF7-005
ATF7-006
ATF7-007
ATF7-009
ATF7-010
ATF7-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATF7-001
ENSP00000399465
ENST00000420353
P17544 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0034399 [nuclear periphery]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 483 aa
51.8 kDa 		No 0
ATF7-002
ENSP00000465192
ENST00000591397
P17544 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0034399 [nuclear periphery]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 117 aa
13.3 kDa 		No 1
ATF7-005
ENSP00000449817
ENST00000551480
F8VWG7 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
8.3 kDa 		No 0
ATF7-006
ENSP00000387406
ENST00000456903
P17544 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0034399 [nuclear periphery]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 483 aa
51.8 kDa 		No 0
ATF7-007
ENSP00000449938
ENST00000548446
P17544 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0034399 [nuclear periphery]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 494 aa
53 kDa 		No 0
ATF7-009
ENSP00000456858
ENST00000548118
P17544 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0016032 [viral process]
GO:0019899 [enzyme binding]
GO:0034399 [nuclear periphery]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 117 aa
13.3 kDa 		No 1
ATF7-010
ENSP00000465850
ENST00000588232
K7EKZ7 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 79 aa
8.4 kDa 		No 0
ATF7-011
ENSP00000468623
ENST00000588078
K7ESA4 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
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 163 aa
17.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.