Expression of MURC in cancer - Summary - The Human Protein Atlas

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MURC

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MURC
Gene description	Muscle-related coiled-coil protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (NTERA-2, SCLC-21H)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly specific expression in membranes of striated muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA020973 , HPA020987 , HPA021021
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020973	HPA020987	HPA021021

GENE INFORMATION
Gene name	MURC (HGNC Symbol)
Synonyms	cavin-4, CAVIN4
Description	Muscle-related coiled-coil protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]
Chromosome	9
Cytoband	q31.1
Chromosome location (bp)	100578079 - 100587906
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170681 (version 83.38)
Entrez gene	347273
UniProt	Q5BKX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q5BKX8
Antibodypedia	MURC antibodies

PROTEIN BROWSER

MURC-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MURC-001 ENSP00000418668 ENST00000307584	Q5BKX8 [Direct mapping] Muscle-related coiled-coil protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007517 [muscle organ development] GO:0010468 [regulation of gene expression] GO:0030154 [cell differentiation] Show all	364 aa 41.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.