Expression of CEL in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CEL
Gene description	Carboxyl ester lipase
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in exocrine glandular cells of pancreas and glandular cells in lactating breast.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA008023 , HPA052701
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA008023	HPA052701

GENE INFORMATION
Gene name	CEL (HGNC Symbol)
Synonyms	BSSL, MODY8
Description	Carboxyl ester lipase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.13
Chromosome location (bp)	133061978 - 133087355
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170835 (version 83.38)
Entrez gene	1056
UniProt
neXtProt
Antibodypedia	CEL antibodies

PROTEIN BROWSER

CEL-001	CEL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEL-001 ENSP00000361151 ENST00000372080	X6R868 [Direct mapping] Carboxylic ester hydrolase Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0004771 [sterol esterase activity] GO:0004806 [triglyceride lipase activity] GO:0005615 [extracellular space] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0032403 [protein complex binding] GO:0042572 [retinol metabolic process] GO:0042588 [zymogen granule] GO:0043208 [glycosphingolipid binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0046514 [ceramide catabolic process] GO:0050253 [retinyl-palmitate esterase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	756 aa 79.7 kDa	Yes	0
CEL-201 ENSP00000480238 ENST00000621209	Q14018 [Direct mapping] Bile salt-activated lipase; Carboxyl ester lipase (Bile salt-stimulated lipase), isoform CRA_a; Carboxyl ester lipase-like protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	59 aa 6.2 kDa	Yes	0