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CEL

GENERAL INFORMATION

Gene name

 CEL

Gene description

 Carboxyl ester lipase

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (pancreas)
GTEx:Tissue enriched (pancreas)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in exocrine glandular cells of pancreas and glandular cells in lactating breast.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA008023 , HPA052701
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Lactating breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 CEL (HGNC Symbol)

Synonyms

 BSSL, MODY8

Description

 Carboxyl ester lipase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.13

Chromosome location (bp)

 133061978 - 133087355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170835 (version 83.38)

Entrez gene

 1056

UniProt

neXtProt

Antibodypedia

 CEL antibodies

PROTEIN BROWSER
CEL-001
CEL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEL-001
ENSP00000361151
ENST00000372080
X6R868 [Direct mapping]
Carboxylic ester hydrolase
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004622 [lysophospholipase activity]
GO:0004771 [sterol esterase activity]
GO:0004806 [triglyceride lipase activity]
GO:0005615 [extracellular space]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0032403 [protein complex binding]
GO:0042572 [retinol metabolic process]
GO:0042588 [zymogen granule]
GO:0043208 [glycosphingolipid binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0046514 [ceramide catabolic process]
GO:0050253 [retinyl-palmitate esterase activity]
GO:0052689 [carboxylic ester hydrolase activity]
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 756 aa
79.7 kDa 		Yes 0
CEL-201
ENSP00000480238
ENST00000621209
Q14018 [Direct mapping]
Bile salt-activated lipase; Carboxyl ester lipase (Bile salt-stimulated lipase), isoform CRA_a; Carboxyl ester lipase-like protein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
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 59 aa
6.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.