Expression of PSG6 in cancer - Summary - The Human Protein Atlas

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PSG6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSG6
Gene description	Pregnancy specific beta-1-glycoprotein 6
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (U-2197)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046327

GENE INFORMATION
Gene name	PSG6
Synonyms
Description	Pregnancy specific beta-1-glycoprotein 6 (HGNC Symbol)
Entrez gene summary	This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	42902079 - 42919563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170848 (version 83.38)
Entrez gene	5675
UniProt	Q00889 (UniProt - Evidence at transcript level)
neXtProt	NX_Q00889
Antibodypedia	PSG6 antibodies

PROTEIN BROWSER

PSG6-001	PSG6-002	PSG6-003	PSG6-006	PSG6-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSG6-001 ENSP00000187910 ENST00000187910	Q00889 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	424 aa 47.5 kDa	Yes	0
PSG6-002 ENSP00000292125 ENST00000292125	Q00889 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	435 aa 48.8 kDa	Yes	0
PSG6-003 ENSP00000385736 ENST00000402603	B5MCE1 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	331 aa 36.7 kDa	Yes	0
PSG6-006 ENSP00000470412 ENST00000594375	M0QZA7 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	158 aa 17.9 kDa	No	0
PSG6-009 ENSP00000469423 ENST00000601833	M0QXW0 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	73 aa 8.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.