Expression of RNF139 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

RNF139

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF139
Gene description	Ring finger protein 139
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA001202
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001202

GENE INFORMATION
Gene name	RNF139 (HGNC Symbol)
Synonyms	HRCA1, RCA1, TRC8
Description	Ring finger protein 139 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.13
Chromosome location (bp)	124474738 - 124487914
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170881 (version 83.38)
Entrez gene	11236
UniProt	Q8WU17 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WU17
Antibodypedia	RNF139 antibodies

PROTEIN BROWSER

RNF139-001	RNF139-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF139-001 ENSP00000304051 ENST00000303545	Q8WU17 [Direct mapping] E3 ubiquitin-protein ligase RNF139 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0017148 [negative regulation of translation] GO:0019787 [ubiquitin-like protein transferase activity] GO:0031396 [regulation of protein ubiquitination] GO:0031648 [protein destabilization] GO:0036503 [ERAD pathway] GO:0036513 [Derlin-1 retrotranslocation complex] GO:0060628 [regulation of ER to Golgi vesicle-mediated transport] GO:0070613 [regulation of protein processing] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] Show all	664 aa 76 kDa	No	>9
RNF139-002 ENSP00000429836 ENST00000517684	E5RH85 [Direct mapping] E3 ubiquitin-protein ligase RNF139 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.