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RNF139

GENERAL INFORMATION

Gene name

 RNF139

Gene description

 Ring finger protein 139

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA001202
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RNF139 (HGNC Symbol)

Synonyms

 HRCA1, RCA1, TRC8

Description

 Ring finger protein 139 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.13

Chromosome location (bp)

 124474738 - 124487914

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170881 (version 83.38)

Entrez gene

 11236

UniProt

 Q8WU17 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WU17

Antibodypedia

 RNF139 antibodies

PROTEIN BROWSER
RNF139-001
RNF139-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF139-001
ENSP00000304051
ENST00000303545
Q8WU17 [Direct mapping]
E3 ubiquitin-protein ligase RNF139
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017148 [negative regulation of translation]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0031396 [regulation of protein ubiquitination]
GO:0031648 [protein destabilization]
GO:0036503 [ERAD pathway]
GO:0036513 [Derlin-1 retrotranslocation complex]
GO:0060628 [regulation of ER to Golgi vesicle-mediated transport]
GO:0070613 [regulation of protein processing]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
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 664 aa
76 kDa 		No >9
RNF139-002
ENSP00000429836
ENST00000517684
E5RH85 [Direct mapping]
E3 ubiquitin-protein ligase RNF139
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
 68 aa
7.5 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.