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Phospholipase A2, group IB (pancreas) (HGNC Symbol)
Entrez gene summary
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000187 [activation of MAPK activity] GO:0002227 [innate immune response in mucosa] GO:0002446 [neutrophil mediated immunity] GO:0004623 [phospholipase A2 activity] GO:0005102 [receptor binding] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006633 [fatty acid biosynthetic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0007015 [actin filament organization] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010524 [positive regulation of calcium ion transport into cytosol] GO:0015758 [glucose transport] GO:0016042 [lipid catabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0019731 [antibacterial humoral response] GO:0030141 [secretory granule] GO:0030593 [neutrophil chemotaxis] GO:0032052 [bile acid binding] GO:0032431 [activation of phospholipase A2 activity] GO:0032637 [interleukin-8 production] GO:0032869 [cellular response to insulin stimulus] GO:0035556 [intracellular signal transduction] GO:0036148 [phosphatidylglycerol acyl-chain remodeling] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0036150 [phosphatidylserine acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044240 [multicellular organismal lipid catabolic process] GO:0044281 [small molecule metabolic process] GO:0045740 [positive regulation of DNA replication] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046470 [phosphatidylcholine metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047498 [calcium-dependent phospholipase A2 activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050482 [arachidonic acid secretion] GO:0050714 [positive regulation of protein secretion] GO:0050778 [positive regulation of immune response] GO:0050830 [defense response to Gram-positive bacterium] GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
