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NUDT6

GENERAL INFORMATION

Gene name

 NUDT6

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA039202 , HPA066115
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039202
HPA066115

GENE INFORMATION

Gene name

 NUDT6 (HGNC Symbol)

Synonyms

 FGF-AS, FGF2AS, gfg, gfg-1

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 6 (HGNC Symbol)

Entrez gene summary

 This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 4

Cytoband

 q28.1

Chromosome location (bp)

 122888697 - 122922968

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170917 (version 83.38)

Entrez gene

 11162

UniProt

 P53370 (UniProt - Evidence at protein level)

neXtProt

 NX_P53370

Antibodypedia

 NUDT6 antibodies

PROTEIN BROWSER
NUDT6-001
NUDT6-002
NUDT6-004
NUDT6-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT6-001
ENSP00000306070
ENST00000304430
P53370 [Direct mapping]
Nucleoside diphosphate-linked moiety X motif 6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0008083 [growth factor activity]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 316 aa
35.7 kDa 		No 0
NUDT6-002
ENSP00000344011
ENST00000339154
P53370 [Direct mapping]
Nucleoside diphosphate-linked moiety X motif 6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0008083 [growth factor activity]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 147 aa
17.1 kDa 		No 0
NUDT6-004
ENSP00000423745
ENST00000510735
H0Y9C0 [Direct mapping]
Nucleoside diphosphate-linked moiety X motif 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 50 aa
5.5 kDa 		No 0
NUDT6-007
ENSP00000424117
ENST00000502270
P53370 [Direct mapping]
Nucleoside diphosphate-linked moiety X motif 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0008083 [growth factor activity]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 147 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.