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Weak to moderate cytoplasmic staining was observed in most malignancies. Several endometrial and thyroid cancers as well as malignant gliomas were strongly stained.
GENE INFORMATION
Gene name
S1PR1 (HGNC Symbol)
Synonyms
CD363, D1S3362, edg-1, EDG1
Description
Sphingosine-1-phosphate receptor 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]