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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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S1PR1
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

S1PR1

Gene description

Sphingosine-1-phosphate receptor 1

Protein class

Cancer-related genes
CD markers
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic and membranous expression. Distinct expression in endothelial cells, fibroblast and in the brain.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images. Pending retesting.

Reliability score

Supported based on 1 antibody.
CAB010104
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

S1PR1 (HGNC Symbol)

Synonyms

CD363, D1S3362, edg-1, EDG1

Description

Sphingosine-1-phosphate receptor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p21.2

Chromosome location (bp)

101236888 - 101241518

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170989 (version 83.38)

Entrez gene

1901

UniProt

P21453 (UniProt - Evidence at protein level)

neXtProt

NX_P21453

Antibodypedia

S1PR1 antibodies

PROTEIN BROWSER

S1PR1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

S1PR1-001
ENSP00000305416
ENST00000305352
P21453 [Direct mapping]
Sphingosine 1-phosphate receptor 1
Show all
CD markers
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Lysolipids receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001664 [G-protein coupled receptor binding]
GO:0001955 [blood vessel maturation]
GO:0003245 [cardiac muscle tissue growth involved in heart morphogenesis]
GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0007155 [cell adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0019226 [transmission of nerve impulse]
GO:0030032 [lamellipodium assembly]
GO:0030155 [regulation of cell adhesion]
GO:0030182 [neuron differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031532 [actin cytoskeleton reorganization]
GO:0038036 [sphingosine-1-phosphate receptor activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045446 [endothelial cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046625 [sphingolipid binding]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0061384 [heart trabecula morphogenesis]
GO:0072678 [T cell migration]
Show all
382 aa
42.8 kDa
No 7

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