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FEZ2

GENERAL INFORMATION

Gene name

 FEZ2

Gene description

 Fasciculation and elongation protein zeta 2 (zygin II)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA035978
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035978

GENE INFORMATION

Gene name

 FEZ2

Synonyms

Description

 Fasciculation and elongation protein zeta 2 (zygin II) (HGNC Symbol)

Entrez gene summary

 This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p22.2

Chromosome location (bp)

 36531805 - 36646087

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171055 (version 83.38)

Entrez gene

 9637

UniProt

 Q9UHY8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHY8

Antibodypedia

 FEZ2 antibodies

PROTEIN BROWSER
FEZ2-001
FEZ2-002
FEZ2-003
FEZ2-013
FEZ2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FEZ2-001
ENSP00000368547
ENST00000379245
Q9UHY8 [Direct mapping]
Fasciculation and elongation protein zeta-2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:1902902 [negative regulation of autophagosome assembly]
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 380 aa
42.6 kDa 		No 0
FEZ2-002
ENSP00000385112
ENST00000405912
Q9UHY8 [Direct mapping]
Fasciculation and elongation protein zeta-2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:1902902 [negative regulation of autophagosome assembly]
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 353 aa
39.7 kDa 		No 0
FEZ2-003
ENSP00000415325
ENST00000441005
H7C434 [Direct mapping]
Fasciculation and elongation protein zeta-2
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 183 aa
20.8 kDa 		No 0
FEZ2-013
ENSP00000350685
ENST00000357996
F8W6C0 [Direct mapping]
Fasciculation and elongation protein zeta-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 246 aa
28.3 kDa 		No 0
FEZ2-201
ENSP00000305843
ENST00000305852
Q7Z674 [Direct mapping]
Fasciculation and elongation protein zeta 2 (Zygin II), isoform CRA_d; Fasciculation and elongation protein zeta-2; Putative uncharacterized protein DKFZp779C2259
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 182 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.