Tissue expression of FEZ2 - Summary - The Human Protein Atlas

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FEZ2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FEZ2
Gene description	Fasciculation and elongation protein zeta 2 (zygin II)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA035978
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FEZ2
Synonyms
Description	Fasciculation and elongation protein zeta 2 (zygin II) (HGNC Symbol)
Entrez gene summary	This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p22.2
Chromosome location (bp)	36531805 - 36646087
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171055 (version 83.38)
Entrez gene	9637
UniProt	Q9UHY8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHY8
Antibodypedia	FEZ2 antibodies

PROTEIN BROWSER

FEZ2-001	FEZ2-002	FEZ2-003	FEZ2-013	FEZ2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FEZ2-001 ENSP00000368547 ENST00000379245	Q9UHY8 [Direct mapping] Fasciculation and elongation protein zeta-2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:1902902 [negative regulation of autophagosome assembly] Show all	380 aa 42.6 kDa	No	0
FEZ2-002 ENSP00000385112 ENST00000405912	Q9UHY8 [Direct mapping] Fasciculation and elongation protein zeta-2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:1902902 [negative regulation of autophagosome assembly] Show all	353 aa 39.7 kDa	No	0
FEZ2-003 ENSP00000415325 ENST00000441005	H7C434 [Direct mapping] Fasciculation and elongation protein zeta-2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		183 aa 20.8 kDa	No	0
FEZ2-013 ENSP00000350685 ENST00000357996	F8W6C0 [Direct mapping] Fasciculation and elongation protein zeta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		246 aa 28.3 kDa	No	0
FEZ2-201 ENSP00000305843 ENST00000305852	Q7Z674 [Direct mapping] Fasciculation and elongation protein zeta 2 (Zygin II), isoform CRA_d; Fasciculation and elongation protein zeta-2; Putative uncharacterized protein DKFZp779C2259 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		182 aa 20.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.