Tissue expression of FUT3 - Summary - The Human Protein Atlas

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FUT3

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FUT3
Gene description	Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Protein class	Blood group antigen proteins Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (colon, esophagus, small intestine)
GTEx:	Tissue enhanced (esophagus, salivary gland)
FANTOM5:	Tissue enhanced (colon, small intestine, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in gastrointestinal tract.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA046966
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, esophagus, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, small intestine, tonsil)

GENE INFORMATION
Gene name	FUT3 (HGNC Symbol)
Synonyms	CD174, LE
Description	Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) (HGNC Symbol)
Entrez gene summary	The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	5842888 - 5851474
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171124 (version 83.38)
Entrez gene	2525
UniProt	P21217 (UniProt - Evidence at transcript level)
neXtProt	NX_P21217
Antibodypedia	FUT3 antibodies

PROTEIN BROWSER

FUT3-001	FUT3-002	FUT3-003	FUT3-004	FUT3-008	FUT3-009	FUT3-011	FUT3-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FUT3-001 ENSP00000468123 ENST00000589918	P21217 [Direct mapping] Galactoside 3(4)-L-fucosyltransferase Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0009312 [oligosaccharide biosynthetic process] GO:0009988 [cell-cell recognition] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0043413 [macromolecule glycosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	361 aa 42.1 kDa	No	0
FUT3-002 ENSP00000305603 ENST00000303225	P21217 [Direct mapping] Galactoside 3(4)-L-fucosyltransferase Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0009312 [oligosaccharide biosynthetic process] GO:0009988 [cell-cell recognition] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0043413 [macromolecule glycosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	361 aa 42.1 kDa	No	0
FUT3-003 ENSP00000465804 ENST00000589620	P21217 [Direct mapping] Galactoside 3(4)-L-fucosyltransferase Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0009312 [oligosaccharide biosynthetic process] GO:0009988 [cell-cell recognition] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0043413 [macromolecule glycosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	361 aa 42.1 kDa	No	0
FUT3-004 ENSP00000416443 ENST00000458379	P21217 [Direct mapping] Galactoside 3(4)-L-fucosyltransferase Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0009312 [oligosaccharide biosynthetic process] GO:0009988 [cell-cell recognition] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017060 [3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0043413 [macromolecule glycosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046920 [alpha-(1->3)-fucosyltransferase activity] GO:0070062 [extracellular exosome] Show all	361 aa 42.1 kDa	No	0
FUT3-008 ENSP00000467081 ENST00000589714	K7ENT3 [Direct mapping] Galactoside 3(4)-L-fucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	107 aa 11.9 kDa	No	1
FUT3-009 ENSP00000468515 ENST00000587048	K7ES24 [Direct mapping] Galactoside 3(4)-L-fucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	100 aa 11.2 kDa	No	1
FUT3-011 ENSP00000468795 ENST00000587183		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		5 aa 0.5 kDa	No	0
FUT3-012 ENSP00000467633 ENST00000585715	K7EQ20 [Direct mapping] Galactoside 3(4)-L-fucosyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008417 [fucosyltransferase activity] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	44 aa 5 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.