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SOCS5

GENERAL INFORMATION

Gene name

 SOCS5

Gene description

 Suppressor of cytokine signaling 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA020884 , CAB025510
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (unfavourable).
Liver cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020884
CAB025510

GENE INFORMATION

Gene name

 SOCS5 (HGNC Symbol)

Synonyms

 CIS6, Cish5, CISH6, KIAA0671, SOCS-5

Description

 Suppressor of cytokine signaling 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 46698952 - 46763129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171150 (version 83.38)

Entrez gene

 9655

UniProt

 O75159 (UniProt - Evidence at protein level)

neXtProt

 NX_O75159

Antibodypedia

 SOCS5 antibodies

PROTEIN BROWSER
SOCS5-001
SOCS5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOCS5-001
ENSP00000305133
ENST00000306503
O75159 [Direct mapping]
Suppressor of cytokine signaling 5
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Predicted intracellular proteins
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GO:0004860 [protein kinase inhibitor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0009968 [negative regulation of signal transduction]
GO:0016049 [cell growth]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0040008 [regulation of growth]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045629 [negative regulation of T-helper 2 cell differentiation]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 536 aa
61.2 kDa 		No 0
SOCS5-002
ENSP00000378330
ENST00000394861
O75159 [Direct mapping]
Suppressor of cytokine signaling 5
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Predicted intracellular proteins
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0009968 [negative regulation of signal transduction]
GO:0016049 [cell growth]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0040008 [regulation of growth]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045629 [negative regulation of T-helper 2 cell differentiation]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 536 aa
61.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.