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SOCS5

GENERAL INFORMATION

Gene name

 SOCS5

Gene description

 Suppressor of cytokine signaling 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA020884 , CAB025510
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SOCS5 (HGNC Symbol)

Synonyms

 CIS6, Cish5, CISH6, KIAA0671, SOCS-5

Description

 Suppressor of cytokine signaling 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p21

Chromosome location (bp)

 46698952 - 46763129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171150 (version 83.38)

Entrez gene

 9655

UniProt

 O75159 (UniProt - Evidence at protein level)

neXtProt

 NX_O75159

Antibodypedia

 SOCS5 antibodies

PROTEIN BROWSER
SOCS5-001
SOCS5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOCS5-001
ENSP00000305133
ENST00000306503
O75159 [Direct mapping]
Suppressor of cytokine signaling 5
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Predicted intracellular proteins
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GO:0004860 [protein kinase inhibitor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0009968 [negative regulation of signal transduction]
GO:0016049 [cell growth]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0040008 [regulation of growth]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045629 [negative regulation of T-helper 2 cell differentiation]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 536 aa
61.2 kDa 		No 0
SOCS5-002
ENSP00000378330
ENST00000394861
O75159 [Direct mapping]
Suppressor of cytokine signaling 5
Show all
Predicted intracellular proteins
Show all
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0009968 [negative regulation of signal transduction]
GO:0016049 [cell growth]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0040008 [regulation of growth]
GO:0045627 [positive regulation of T-helper 1 cell differentiation]
GO:0045629 [negative regulation of T-helper 2 cell differentiation]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 536 aa
61.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.