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KRT19

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GENERAL INFORMATION

Gene name

 KRT19

Gene description

 Keratin 19, type I

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the intermediate filaments.

RNA cell category

 Cell line enhanced (SK-BR-3, T-47d, RT4)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Intermediate filaments (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA002465
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-BR-3, T-47d, RT4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the intermediate filaments.

Main location

 Intermediate filaments (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA002465 MCF7 Intermediate filaments Intensity
HPA002465 RT4 Intermediate filaments Intensity

GENE INFORMATION

Gene name

 KRT19 (HGNC Symbol)

Synonyms

 CK19, K19, K1CS, MGC15366

Description

 Keratin 19, type I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41523617 - 41528308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171345 (version 83.38)

Entrez gene

 3880

UniProt

 P08727 (UniProt - Evidence at protein level)

neXtProt

 NX_P08727

Antibodypedia

 KRT19 antibodies

PROTEIN BROWSER
KRT19-001
KRT19-002
KRT19-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT19-001
ENSP00000355124
ENST00000361566
P08727 [Direct mapping]
Keratin, type I cytoskeletal 19
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0007219 [Notch signaling pathway]
GO:0008307 [structural constituent of muscle]
GO:0016010 [dystrophin-associated glycoprotein complex]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0032403 [protein complex binding]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0043627 [response to estrogen]
GO:0045214 [sarcomere organization]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:1990357 [terminal web]
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 400 aa
44.1 kDa 		No 0
KRT19-002
ENSP00000408759
ENST00000455635
C9JM50 [Direct mapping]
Keratin, type I cytoskeletal 19
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 196 aa
20.8 kDa 		No 0
KRT19-007
ENSP00000466625
ENST00000593096
K7EMS3 [Direct mapping]
Keratin, type I cytoskeletal 19
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 181 aa
20.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.