Expression of KRT19 in cancer - Summary

GENERAL INFORMATION
Gene name	KRT19
Gene description	Keratin 19, type I
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RT4, SK-BR-3, T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in glandular, respiratory and squamous epithelium as well as renal tubules, exocrine pancreas and trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA002465 , CAB000031
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002465	CAB000031

GENE INFORMATION
Gene name	KRT19 (HGNC Symbol)
Synonyms	CK19, K19, K1CS, MGC15366
Description	Keratin 19, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41523617 - 41528308
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171345 (version 83.38)
Entrez gene	3880
UniProt	P08727 (UniProt - Evidence at protein level)
neXtProt	NX_P08727
Antibodypedia	KRT19 antibodies

PROTEIN BROWSER

KRT19-001	KRT19-002	KRT19-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT19-001 ENSP00000355124 ENST00000361566	P08727 [Direct mapping] Keratin, type I cytoskeletal 19 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0005886 [plasma membrane] GO:0007219 [Notch signaling pathway] GO:0008307 [structural constituent of muscle] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016032 [viral process] GO:0030018 [Z disc] GO:0032403 [protein complex binding] GO:0042383 [sarcolemma] GO:0043034 [costamere] GO:0043627 [response to estrogen] GO:0045214 [sarcomere organization] GO:0060706 [cell differentiation involved in embryonic placenta development] GO:0070062 [extracellular exosome] GO:0071944 [cell periphery] GO:1990357 [terminal web] Show all	400 aa 44.1 kDa	No	0
KRT19-002 ENSP00000408759 ENST00000455635	C9JM50 [Direct mapping] Keratin, type I cytoskeletal 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	196 aa 20.8 kDa	No	0
KRT19-007 ENSP00000466625 ENST00000593096	K7EMS3 [Direct mapping] Keratin, type I cytoskeletal 19 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	181 aa 20.2 kDa	No	0