Expression of KRT15 in cancer - Summary

GENERAL INFORMATION
Gene name	KRT15
Gene description	Keratin 15, type I
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer)
HPA (cell line):	Group enriched (HaCaT, hTCEpi)
HPA (normal tissue):	Group enriched (breast, esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in basal cells of the respiratory epithelium, prostate, squamous epithelium and glandular cells of breast.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA023910 , HPA024554
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA023910	HPA024554

GENE INFORMATION
Gene name	KRT15 (HGNC Symbol)
Synonyms	CK15, K15, K1CO
Description	Keratin 15, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41513743 - 41522529
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171346 (version 83.38)
Entrez gene	3866
UniProt	P19012 (UniProt - Evidence at protein level)
neXtProt	NX_P19012
Antibodypedia	KRT15 antibodies

PROTEIN BROWSER

KRT15-001	KRT15-004	KRT15-006	KRT15-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT15-001 ENSP00000254043 ENST00000254043	P19012 [Direct mapping] Keratin, type I cytoskeletal 15 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005882 [intermediate filament] GO:0008544 [epidermis development] GO:0070062 [extracellular exosome] GO:0097110 [scaffold protein binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	456 aa 49.2 kDa	No	0
KRT15-004 ENSP00000377544 ENST00000393974	A8MT21 [Direct mapping] Keratin, type I cytoskeletal 15 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	291 aa 32.7 kDa	No	0
KRT15-006 ENSP00000409282 ENST00000458290	C9JTG5 [Direct mapping] Keratin, type I cytoskeletal 15 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	220 aa 24.9 kDa	No	0
KRT15-007 ENSP00000377546 ENST00000393976	P19012 [Direct mapping] Keratin, type I cytoskeletal 15 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005882 [intermediate filament] GO:0008544 [epidermis development] GO:0070062 [extracellular exosome] GO:0097110 [scaffold protein binding] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	456 aa 49.2 kDa	No	0