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KRT15

GENERAL INFORMATION

Gene name

 KRT15

Gene description

 Keratin 15, type I

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (breast, esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin, vagina)
FANTOM5:Tissue enhanced (gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in basal cells of the respiratory epithelium, prostate, squamous epithelium and glandular cells of breast.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA023910 , HPA024554
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (breast, esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder)

GENE INFORMATION

Gene name

 KRT15 (HGNC Symbol)

Synonyms

 CK15, K15, K1CO

Description

 Keratin 15, type I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41513743 - 41522529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171346 (version 83.38)

Entrez gene

 3866

UniProt

 P19012 (UniProt - Evidence at protein level)

neXtProt

 NX_P19012

Antibodypedia

 KRT15 antibodies

PROTEIN BROWSER
KRT15-001
KRT15-004
KRT15-006
KRT15-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT15-001
ENSP00000254043
ENST00000254043
P19012 [Direct mapping]
Keratin, type I cytoskeletal 15
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0008544 [epidermis development]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 456 aa
49.2 kDa 		No 0
KRT15-004
ENSP00000377544
ENST00000393974
A8MT21 [Direct mapping]
Keratin, type I cytoskeletal 15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 291 aa
32.7 kDa 		No 0
KRT15-006
ENSP00000409282
ENST00000458290
C9JTG5 [Direct mapping]
Keratin, type I cytoskeletal 15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
Show all
 220 aa
24.9 kDa 		No 0
KRT15-007
ENSP00000377546
ENST00000393976
P19012 [Direct mapping]
Keratin, type I cytoskeletal 15
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0008544 [epidermis development]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 456 aa
49.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.