Cell atlas - KCND3 - The Human Protein Atlas

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KCND3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	KCND3
Gene description	Potassium channel, voltage gated Shal related subfamily D, member 3
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SCLC-21H, WM-115)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	KCND3 (HGNC Symbol)
Synonyms	KSHIVB, Kv4.3, SCA19, SCA22
Description	Potassium channel, voltage gated Shal related subfamily D, member 3 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	111770662 - 111989155
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171385 (version 83.38)
Entrez gene	3752
UniProt	Q9UK17 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UK17
Antibodypedia	KCND3 antibodies

PROTEIN BROWSER

KCND3-001	KCND3-002	KCND3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCND3-001 ENSP00000319591 ENST00000315987	Q9UK17 [Direct mapping] Potassium voltage-gated channel subfamily D member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005250 [A-type (transient outward) potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034765 [regulation of ion transmembrane transport] GO:0042383 [sarcolemma] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0044325 [ion channel binding] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071435 [potassium ion export] GO:0071773 [cellular response to BMP stimulus] GO:0086009 [membrane repolarization] GO:0097038 [perinuclear endoplasmic reticulum] Show all	655 aa 73.5 kDa	Yes	6
KCND3-002 ENSP00000358711 ENST00000369697	Q9UK17 [Direct mapping] Potassium voltage-gated channel subfamily D member 3 A0A024R0C6 [Target identity:100%; Query identity:100%] Potassium voltage-gated channel, Shal-related subfamily, member 3, isoform CRA_b Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005250 [A-type (transient outward) potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034765 [regulation of ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071435 [potassium ion export] GO:0086009 [membrane repolarization] Show all	636 aa 71.4 kDa	Yes	6
KCND3-201 ENSP00000306923 ENST00000302127	Q9UK17 [Direct mapping] Potassium voltage-gated channel subfamily D member 3 A0A024R0C6 [Target identity:100%; Query identity:100%] Potassium voltage-gated channel, Shal-related subfamily, member 3, isoform CRA_b Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005250 [A-type (transient outward) potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034765 [regulation of ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071435 [potassium ion export] GO:0086009 [membrane repolarization] Show all	636 aa 71.4 kDa	Yes	6

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.