Tissue expression of KCND3 - Summary - The Human Protein Atlas

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KCND3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KCND3
Gene description	Potassium channel, voltage gated Shal related subfamily D, member 3
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (cerebellum)
FANTOM5:	Tissue enriched (cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues, including the CNS.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA029452
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION
Gene name	KCND3 (HGNC Symbol)
Synonyms	KSHIVB, Kv4.3, SCA19, SCA22
Description	Potassium channel, voltage gated Shal related subfamily D, member 3 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	111770662 - 111989155
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171385 (version 83.38)
Entrez gene	3752
UniProt	Q9UK17 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UK17
Antibodypedia	KCND3 antibodies

PROTEIN BROWSER

KCND3-001	KCND3-002	KCND3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCND3-001 ENSP00000319591 ENST00000315987	Q9UK17 [Direct mapping] Potassium voltage-gated channel subfamily D member 3 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005250 [A-type (transient outward) potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034765 [regulation of ion transmembrane transport] GO:0042383 [sarcolemma] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0044325 [ion channel binding] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071435 [potassium ion export] GO:0071773 [cellular response to BMP stimulus] GO:0086009 [membrane repolarization] GO:0097038 [perinuclear endoplasmic reticulum] Show all	655 aa 73.5 kDa	Yes	6
KCND3-002 ENSP00000358711 ENST00000369697	Q9UK17 [Direct mapping] Potassium voltage-gated channel subfamily D member 3 A0A024R0C6 [Target identity:100%; Query identity:100%] Potassium voltage-gated channel, Shal-related subfamily, member 3, isoform CRA_b Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005250 [A-type (transient outward) potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034765 [regulation of ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071435 [potassium ion export] GO:0086009 [membrane repolarization] Show all	636 aa 71.4 kDa	Yes	6
KCND3-201 ENSP00000306923 ENST00000302127	Q9UK17 [Direct mapping] Potassium voltage-gated channel subfamily D member 3 A0A024R0C6 [Target identity:100%; Query identity:100%] Potassium voltage-gated channel, Shal-related subfamily, member 3, isoform CRA_b Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005250 [A-type (transient outward) potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0034765 [regulation of ion transmembrane transport] GO:0042383 [sarcolemma] GO:0044325 [ion channel binding] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071435 [potassium ion export] GO:0086009 [membrane repolarization] Show all	636 aa 71.4 kDa	Yes	6

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