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APLN

GENERAL INFORMATION

Gene name

 APLN

Gene description

 Apelin

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, renal cancer)
HPA (cell line):Cell line enriched (HUVEC TERT2)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable), lung cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Lung cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 APLN (HGNC Symbol)

Synonyms

 apelin, XNPEP2

Description

 Apelin (HGNC Symbol)

Entrez gene summary

 This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]

Chromosome

 X

Cytoband

 q26.1

Chromosome location (bp)

 129645259 - 129654937

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000171388 (version 83.38)

Entrez gene

 8862

UniProt

 Q9ULZ1 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9ULZ1

Antibodypedia

 APLN antibodies

PROTEIN BROWSER
APLN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APLN-001
ENSP00000391800
ENST00000429967
Q9ULZ1 [Direct mapping]
Apelin Apelin-36 Apelin-31 Apelin-28 Apelin-13
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0001664 [G-protein coupled receptor binding]
GO:0002026 [regulation of the force of heart contraction]
GO:0005102 [receptor binding]
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007595 [lactation]
GO:0007631 [feeding behavior]
GO:0008284 [positive regulation of cell proliferation]
GO:0031652 [positive regulation of heat generation]
GO:0031704 [apelin receptor binding]
GO:0042327 [positive regulation of phosphorylation]
GO:0042756 [drinking behavior]
GO:0043576 [regulation of respiratory gaseous exchange]
GO:0045776 [negative regulation of blood pressure]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050878 [regulation of body fluid levels]
GO:0051461 [positive regulation of corticotropin secretion]
GO:0051466 [positive regulation of corticotropin-releasing hormone secretion]
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 77 aa
8.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.