Tissue expression of APLN - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	APLN
Gene description	Apelin
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	APLN (HGNC Symbol)
Synonyms	apelin, XNPEP2
Description	Apelin (HGNC Symbol)
Entrez gene summary	This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]
Chromosome	X
Cytoband	q26.1
Chromosome location (bp)	129645259 - 129654937
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000171388 (version 83.38)
Entrez gene	8862
UniProt	Q9ULZ1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9ULZ1
Antibodypedia	APLN antibodies

PROTEIN BROWSER

APLN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APLN-001 ENSP00000391800 ENST00000429967	Q9ULZ1 [Direct mapping] Apelin Apelin-36 Apelin-31 Apelin-28 Apelin-13 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001664 [G-protein coupled receptor binding] GO:0002026 [regulation of the force of heart contraction] GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007595 [lactation] GO:0007631 [feeding behavior] GO:0008284 [positive regulation of cell proliferation] GO:0031652 [positive regulation of heat generation] GO:0031704 [apelin receptor binding] GO:0042327 [positive regulation of phosphorylation] GO:0042756 [drinking behavior] GO:0043576 [regulation of respiratory gaseous exchange] GO:0045776 [negative regulation of blood pressure] GO:0045906 [negative regulation of vasoconstriction] GO:0045909 [positive regulation of vasodilation] GO:0048471 [perinuclear region of cytoplasm] GO:0050878 [regulation of body fluid levels] GO:0051461 [positive regulation of corticotropin secretion] GO:0051466 [positive regulation of corticotropin-releasing hormone secretion] Show all	77 aa 8.6 kDa	Yes	0