Expression of PDE7B in cancer - Summary - The Human Protein Atlas

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PDE7B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDE7B
Gene description	Phosphodiesterase 7B
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (EFO-21, HUVEC TERT2, U-2197)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA023967
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023967

GENE INFORMATION
Gene name	PDE7B
Synonyms
Description	Phosphodiesterase 7B (HGNC Symbol)
Entrez gene summary	The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]
Chromosome	6
Cytoband	q23.3
Chromosome location (bp)	135851696 - 136195574
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171408 (version 83.38)
Entrez gene	27115
UniProt	Q9NP56 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP56
Antibodypedia	PDE7B antibodies

PROTEIN BROWSER

PDE7B-001	PDE7B-002	PDE7B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE7B-001 ENSP00000310661 ENST00000308191	Q9NP56 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 7B Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0008081 [phosphoric diester hydrolase activity] GO:0046872 [metal ion binding] Show all	450 aa 51.8 kDa	No	0
PDE7B-002 ENSP00000403732 ENST00000446774	H0Y689 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 7B Show all	Predicted intracellular proteins Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	200 aa 22.9 kDa	No	0
PDE7B-201 ENSP00000482117 ENST00000615259	A1E5M1 [Direct mapping] Phosphodiesterase PDE7B2; cAMP-specific 3',5'-cyclic phosphodiesterase 7B Show all	Predicted intracellular proteins Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	502 aa 57.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.