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PDE7B

GENERAL INFORMATION

Gene name

 PDE7B

Gene description

 Phosphodiesterase 7B

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 RNA-based expert annotation gave inconclusive results.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA023967
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 PDE7B

Synonyms

Description

 Phosphodiesterase 7B (HGNC Symbol)

Entrez gene summary

 The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.[provided by RefSeq, Apr 2009]

Chromosome

 6

Cytoband

 q23.3

Chromosome location (bp)

 135851696 - 136195574

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171408 (version 83.38)

Entrez gene

 27115

UniProt

 Q9NP56 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP56

Antibodypedia

 PDE7B antibodies

PROTEIN BROWSER
PDE7B-001
PDE7B-002
PDE7B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE7B-001
ENSP00000310661
ENST00000308191
Q9NP56 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0046872 [metal ion binding]
Show all
 450 aa
51.8 kDa 		No 0
PDE7B-002
ENSP00000403732
ENST00000446774
H0Y689 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
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Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
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 200 aa
22.9 kDa 		No 0
PDE7B-201
ENSP00000482117
ENST00000615259
A1E5M1 [Direct mapping]
Phosphodiesterase PDE7B2; cAMP-specific 3',5'-cyclic phosphodiesterase 7B
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Predicted intracellular proteins
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
Show all
 502 aa
57.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.