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KRT20

GENERAL INFORMATION

Gene name

 KRT20

Gene description

 Keratin 20, type I

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, stomach cancer, urothelial cancer)
HPA (cell line):Cell line enhanced (BEWO, RT4)
HPA (normal tissue):Tissue enhanced (colon, duodenum, rectum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in gastrointestinal epithelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA024309 , HPA024684 , HPA027236 , CAB000032
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, stomach cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA024309
HPA024684
HPA027236
CAB000032

GENE INFORMATION

Gene name

 KRT20 (HGNC Symbol)

Synonyms

 CK20, K20, MGC35423

Description

 Keratin 20, type I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 40875941 - 40885227

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171431 (version 83.38)

Entrez gene

 54474

UniProt

 P35900 (UniProt - Evidence at protein level)

neXtProt

 NX_P35900

Antibodypedia

 KRT20 antibodies

PROTEIN BROWSER
KRT20-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT20-001
ENSP00000167588
ENST00000167588
P35900 [Direct mapping]
Keratin, type I cytoskeletal 20
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0006915 [apoptotic process]
GO:0033554 [cellular response to stress]
GO:0045109 [intermediate filament organization]
GO:0050708 [regulation of protein secretion]
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 424 aa
48.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.