Cell atlas - MCC - The Human Protein Atlas

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MCC

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MCC
Gene description	Mutated in colorectal cancers
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA037390
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037390	A-431	Nucleoplasm
	HPA037390	U-2 OS	Nucleoplasm
	HPA037390	U-2 OS	Cytosol
	HPA037390	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	MCC
Synonyms
Description	Mutated in colorectal cancers (HGNC Symbol)
Entrez gene summary	This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q22.2
Chromosome location (bp)	113022099 - 113488830
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171444 (version 83.38)
Entrez gene	4163
UniProt	P23508 (UniProt - Evidence at protein level)
neXtProt	NX_P23508
Antibodypedia	MCC antibodies

PROTEIN BROWSER

MCC-001	MCC-003	MCC-009	MCC-011	MCC-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCC-001 ENSP00000305617 ENST00000302475	P23508 [Direct mapping] Colorectal mutant cancer protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0010633 [negative regulation of epithelial cell migration] GO:0016055 [Wnt signaling pathway] GO:0030027 [lamellipodium] GO:0045184 [establishment of protein localization] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	829 aa 93 kDa	No	0
MCC-003 ENSP00000386227 ENST00000408903	P23508 [Direct mapping] Colorectal mutant cancer protein Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0010633 [negative regulation of epithelial cell migration] GO:0016055 [Wnt signaling pathway] GO:0030027 [lamellipodium] GO:0045184 [establishment of protein localization] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	1019 aa 113.3 kDa	No	0
MCC-009 ENSP00000485220 ENST00000514701	A0A096LNU0 [Direct mapping] Colorectal mutant cancer protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		715 aa 79.9 kDa	No	0
MCC-011 ENSP00000421615 ENST00000515367	D6REY2 [Direct mapping] Colorectal mutant cancer protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	766 aa 86.1 kDa	No	0
MCC-012 ENSP00000485492 ENST00000624689	A0A096LPB3 [Direct mapping] Colorectal mutant cancer protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.