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MCC

GENERAL INFORMATION

Gene name

 MCC

Gene description

 Mutated in colorectal cancers

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (ovary, parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA037390 , HPA037391
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037390
HPA037391

GENE INFORMATION

Gene name

 MCC

Synonyms

Description

 Mutated in colorectal cancers (HGNC Symbol)

Entrez gene summary

 This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q22.2

Chromosome location (bp)

 113022099 - 113488830

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171444 (version 83.38)

Entrez gene

 4163

UniProt

 P23508 (UniProt - Evidence at protein level)

neXtProt

 NX_P23508

Antibodypedia

 MCC antibodies

PROTEIN BROWSER
MCC-001
MCC-003
MCC-009
MCC-011
MCC-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCC-001
ENSP00000305617
ENST00000302475
P23508 [Direct mapping]
Colorectal mutant cancer protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0016055 [Wnt signaling pathway]
GO:0030027 [lamellipodium]
GO:0045184 [establishment of protein localization]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
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 829 aa
93 kDa 		No 0
MCC-003
ENSP00000386227
ENST00000408903
P23508 [Direct mapping]
Colorectal mutant cancer protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0016055 [Wnt signaling pathway]
GO:0030027 [lamellipodium]
GO:0045184 [establishment of protein localization]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
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 1019 aa
113.3 kDa 		No 0
MCC-009
ENSP00000485220
ENST00000514701
A0A096LNU0 [Direct mapping]
Colorectal mutant cancer protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 715 aa
79.9 kDa 		No 0
MCC-011
ENSP00000421615
ENST00000515367
D6REY2 [Direct mapping]
Colorectal mutant cancer protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 766 aa
86.1 kDa 		No 0
MCC-012
ENSP00000485492
ENST00000624689
A0A096LPB3 [Direct mapping]
Colorectal mutant cancer protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 169 aa
19.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.