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POLR1C

GENERAL INFORMATION

Gene name

 POLR1C

Gene description

 Polymerase (RNA) I polypeptide C, 30kDa

Protein class

 Disease related genes
Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 POLR1C (HGNC Symbol)

Synonyms

 RPA39, RPA40, RPA5, RPAC1

Description

 Polymerase (RNA) I polypeptide C, 30kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS). [provided by RefSeq, Mar 2011]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 43509702 - 43529585

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171453 (version 83.38)

Entrez gene

 9533

UniProt

 O15160 (UniProt - Evidence at protein level)

neXtProt

 NX_O15160

Antibodypedia

 POLR1C antibodies

PROTEIN BROWSER
POLR1C-005
POLR1C-006
POLR1C-007
POLR1C-008
POLR1C-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR1C-005
ENSP00000361419
ENST00000372344
E7EQB9 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0046983 [protein dimerization activity]
Show all
 296 aa
33.8 kDa 		No 0
POLR1C-006
ENSP00000307212
ENST00000304004
O15160 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046983 [protein dimerization activity]
Show all
 342 aa
38.6 kDa 		No 0
POLR1C-007
ENSP00000409536
ENST00000423780
H0Y723 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0046983 [protein dimerization activity]
Show all
 140 aa
16 kDa 		No 0
POLR1C-008
ENSP00000361465
ENST00000372389
O15160 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045087 [innate immune response]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046983 [protein dimerization activity]
Show all
 346 aa
39.2 kDa 		No 0
POLR1C-009
ENSP00000395401
ENST00000428025
D6RDJ3 [Direct mapping]
DNA-directed RNA polymerases I and III subunit RPAC1
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001054 [RNA polymerase I activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0046983 [protein dimerization activity]
Show all
 124 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.