Tissue expression of NLRP5 - Summary - The Human Protein Atlas

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NLRP5

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NLRP5
Gene description	NLR family, pyrin domain containing 5
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (parathyroid gland)
GTEx:	Tissue enhanced (ovary)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA056271
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary)

GENE INFORMATION
Gene name	NLRP5 (HGNC Symbol)
Synonyms	CLR19.8, MATER, NALP5, PAN11, PYPAF8
Description	NLR family, pyrin domain containing 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	55999726 - 56061813
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171487 (version 83.38)
Entrez gene	126206
UniProt	P59047 (UniProt - Evidence at transcript level)
neXtProt	NX_P59047
Antibodypedia	NLRP5 antibodies

PROTEIN BROWSER

NLRP5-001	NLRP5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLRP5-001 ENSP00000375063 ENST00000390649	P59047 [Direct mapping] NACHT, LRR and PYD domains-containing protein 5 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007566 [embryo implantation] GO:0009566 [fertilization] GO:0009887 [organ morphogenesis] GO:0031647 [regulation of protein stability] GO:0034613 [cellular protein localization] GO:0043234 [protein complex] GO:0043487 [regulation of RNA stability] GO:0043623 [cellular protein complex assembly] GO:0045179 [apical cortex] GO:0070997 [neuron death] Show all	1200 aa 134.3 kDa	Yes	0
NLRP5-201 ENSP00000481137 ENST00000621651	A0A087WXM3 [Direct mapping] NACHT, LRR and PYD domains-containing protein 5 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005524 [ATP binding] Show all	1200 aa 134.5 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.