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ECEL1

GENERAL INFORMATION

Gene name

 ECEL1

Gene description

 Endothelin converting enzyme-like 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Group enriched (AN3-CA, HeLa)
HPA (normal tissue):Tissue enriched (ovary)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ECEL1 (HGNC Symbol)

Synonyms

 DINE, XCE

Description

 Endothelin converting enzyme-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 232479827 - 232487828

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171551 (version 83.38)

Entrez gene

 9427

UniProt

 O95672 (UniProt - Evidence at protein level)

neXtProt

 NX_O95672

Antibodypedia

 ECEL1 antibodies

PROTEIN BROWSER
ECEL1-001
ECEL1-003
ECEL1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ECEL1-001
ENSP00000302051
ENST00000304546
O95672 [Direct mapping]
Endothelin-converting enzyme-like 1
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Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003016 [respiratory system process]
GO:0004222 [metalloendopeptidase activity]
GO:0005622 [intracellular]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0007218 [neuropeptide signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 775 aa
87.8 kDa 		No 1
ECEL1-003
ENSP00000386333
ENST00000409941
O95672 [Direct mapping]
Endothelin-converting enzyme-like 1
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003016 [respiratory system process]
GO:0004222 [metalloendopeptidase activity]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0046872 [metal ion binding]
Show all
 773 aa
87.6 kDa 		No 1
ECEL1-005
ENSP00000412683
ENST00000411860
H7C3M0 [Direct mapping]
Endothelin-converting enzyme-like 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0007218 [neuropeptide signaling pathway]
Show all
 168 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.