Tissue expression of ECEL1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ECEL1
Gene description	Endothelin converting enzyme-like 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (ovary)
GTEx:	Group enriched (hypothalamus, ovary, pituitary gland)
FANTOM5:	Group enriched (ovary, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (ovary)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hypothalamus, ovary, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (ovary, retina)

GENE INFORMATION
Gene name	ECEL1 (HGNC Symbol)
Synonyms	DINE, XCE
Description	Endothelin converting enzyme-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	232479827 - 232487828
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171551 (version 83.38)
Entrez gene	9427
UniProt	O95672 (UniProt - Evidence at protein level)
neXtProt	NX_O95672
Antibodypedia	ECEL1 antibodies

PROTEIN BROWSER

ECEL1-001	ECEL1-003	ECEL1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECEL1-001 ENSP00000302051 ENST00000304546	O95672 [Direct mapping] Endothelin-converting enzyme-like 1 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003016 [respiratory system process] GO:0004222 [metalloendopeptidase activity] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007218 [neuropeptide signaling pathway] GO:0008237 [metallopeptidase activity] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	775 aa 87.8 kDa	No	1
ECEL1-003 ENSP00000386333 ENST00000409941	O95672 [Direct mapping] Endothelin-converting enzyme-like 1 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003016 [respiratory system process] GO:0004222 [metalloendopeptidase activity] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0046872 [metal ion binding] Show all	773 aa 87.6 kDa	No	1
ECEL1-005 ENSP00000412683 ENST00000411860	H7C3M0 [Direct mapping] Endothelin-converting enzyme-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007218 [neuropeptide signaling pathway] Show all	168 aa 19.8 kDa	No	0