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BCL2L1

GENERAL INFORMATION

Gene name

 BCL2L1

Gene description

 BCL2-like 1

Protein class

 Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins
RAS pathway related proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a few tissues, including bone marrow, lymph node and cells in tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035734
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (unfavourable), endometrial cancer (unfavourable) and melanoma (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA035734

GENE INFORMATION

Gene name

 BCL2L1 (HGNC Symbol)

Synonyms

 Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52

Description

 BCL2-like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31664452 - 31723989

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171552 (version 83.38)

Entrez gene

 598

UniProt

 Q07817 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07817

Antibodypedia

 BCL2L1 antibodies

PROTEIN BROWSER
BCL2L1-001
BCL2L1-002
BCL2L1-003
BCL2L1-004
BCL2L1-005
BCL2L1-006
BCL2L1-007
BCL2L1-008
BCL2L1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCL2L1-001
ENSP00000365230
ENST00000376062
Q07817 [Direct mapping]
Bcl-2-like protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008637 [apoptotic mitochondrial changes]
GO:0010507 [negative regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019050 [suppression by virus of host apoptotic process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031965 [nuclear membrane]
GO:0034097 [response to cytokine]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0090005 [negative regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000811 [negative regulation of anoikis]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 233 aa
26 kDa 		No 2
BCL2L1-002
ENSP00000365223
ENST00000376055
Q07817 [Direct mapping]
Bcl-2-like protein 1
Q5TE63 [Target identity:100%; Query identity:100%]
BCL2-like 1, isoform CRA_c; cDNA FLJ77105, highly similar to Homo sapiens BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008637 [apoptotic mitochondrial changes]
GO:0010507 [negative regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016021 [integral component of membrane]
GO:0019050 [suppression by virus of host apoptotic process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031965 [nuclear membrane]
GO:0034097 [response to cytokine]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0090005 [negative regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000811 [negative regulation of anoikis]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 170 aa
18.9 kDa 		No 1
BCL2L1-003
ENSP00000406203
ENST00000450273
Q5TE64 [Direct mapping]
Bcl-2-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016020 [membrane]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 205 aa
22.9 kDa 		No 0
BCL2L1-004
ENSP00000302564
ENST00000307677
Q07817 [Direct mapping]
Bcl-2-like protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001541 [ovarian follicle development]
GO:0001701 [in utero embryonic development]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007281 [germ cell development]
GO:0007283 [spermatogenesis]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009314 [response to radiation]
GO:0009566 [fertilization]
GO:0009615 [response to virus]
GO:0010507 [negative regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019050 [suppression by virus of host apoptotic process]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031965 [nuclear membrane]
GO:0031966 [mitochondrial membrane]
GO:0034097 [response to cytokine]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040007 [growth]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0046898 [response to cycloheximide]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0051402 [neuron apoptotic process]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0060154 [cellular process regulating host cell cycle in response to virus]
GO:0070584 [mitochondrion morphogenesis]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071312 [cellular response to alkaloid]
GO:0071480 [cellular response to gamma radiation]
GO:0071839 [apoptotic process in bone marrow]
GO:0090005 [negative regulation of establishment of protein localization to plasma membrane]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097284 [hepatocyte apoptotic process]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage]
GO:2000811 [negative regulation of anoikis]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 233 aa
26 kDa 		No 2
BCL2L1-005
ENSP00000389688
ENST00000439267
Q5QP56 [Direct mapping]
Bcl-2-like protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 181 aa
20.2 kDa 		No 0
BCL2L1-006
ENSP00000390760
ENST00000420488
Q9H1R6 [Direct mapping]
Bcl-2-like protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 188 aa
21 kDa 		No 0
BCL2L1-007
ENSP00000395545
ENST00000456404
Q9H1R6 [Direct mapping]
Bcl-2-like protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 188 aa
21 kDa 		No 0
BCL2L1-008
ENSP00000411252
ENST00000422920
Q9H1R6 [Direct mapping]
Bcl-2-like protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 188 aa
21 kDa 		No 0
BCL2L1-009
ENSP00000401173
ENST00000434194
Q5QP59 [Direct mapping]
Bcl-2-like protein 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 48 aa
5.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.