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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FGA

Gene description

Fibrinogen alpha chain

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct plasma positivity.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 3 antibodies.
HPA051370 , HPA064755 , CAB016776
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA051370
HPA064755
CAB016776

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of hepatocellular carcinoma along with rare pancreatic, lung cancers and melanoma showed moderate cytoplasmic positivity. A single case of carcinoid showed strong positivity. Remaining cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few renal cancers showed moderate cytoplasmic immunoreactivity. Fraction of cells in a single case of hepatocellular carcinoma was strongly stained. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

FGA

Synonyms

Description

Fibrinogen alpha chain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

154583126 - 154590766

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171560 (version 83.38)

Entrez gene

2243

UniProt

P02671 (UniProt - Evidence at protein level)

neXtProt

NX_P02671

Antibodypedia

FGA antibodies

PROTEIN BROWSER

FGA-001
FGA-002
FGA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FGA-001
ENSP00000385981
ENST00000403106
P02671 [Direct mapping]
Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043152 [induction of bacterial agglutination]
GO:0043623 [cellular protein complex assembly]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0072377 [blood coagulation, common pathway]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903561 [extracellular vesicle]
GO:2000261 [negative regulation of blood coagulation, common pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
644 aa
69.8 kDa
Yes 0
FGA-002
ENSP00000306361
ENST00000302053
P02671 [Direct mapping]
Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002576 [platelet degranulation]
GO:0005102 [receptor binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005791 [rough endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006953 [acute-phase response]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030674 [protein binding, bridging]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0031639 [plasminogen activation]
GO:0032355 [response to estradiol]
GO:0033595 [response to genistein]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0042730 [fibrinolysis]
GO:0043152 [induction of bacterial agglutination]
GO:0043278 [response to morphine]
GO:0043623 [cellular protein complex assembly]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045921 [positive regulation of exocytosis]
GO:0046898 [response to cycloheximide]
GO:0050714 [positive regulation of protein secretion]
GO:0050839 [cell adhesion molecule binding]
GO:0051258 [protein polymerization]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071354 [cellular response to interleukin-6]
GO:0071407 [cellular response to organic cyclic compound]
GO:0072377 [blood coagulation, common pathway]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0090277 [positive regulation of peptide hormone secretion]
GO:0097421 [liver regeneration]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1903561 [extracellular vesicle]
GO:1990643 [cellular response to granulocyte colony-stimulating factor]
GO:2000261 [negative regulation of blood coagulation, common pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
866 aa
95 kDa
Yes 0
FGA-201
ENSP00000478487
ENST00000622532
A0A087WUA0 [Direct mapping]
Fibrinogen alpha chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005577 [fibrinogen complex]
GO:0007165 [signal transduction]
GO:0030168 [platelet activation]
GO:0030674 [protein binding, bridging]
GO:0051258 [protein polymerization]
Show all
289 aa
33 kDa
Yes 0

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The Human Protein Atlas project is funded
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