Cell atlas - CLSTN1 - The Human Protein Atlas

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CLSTN1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CLSTN1
Gene description	Calsyntenin 1
Protein class	Cancer-related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CLSTN1 (HGNC Symbol)
Synonyms	CDHR12, CSTN1, KIAA0911
Description	Calsyntenin 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	9729026 - 9824526
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171603 (version 83.38)
Entrez gene	22883
UniProt	O94985 (UniProt - Evidence at protein level)
neXtProt	NX_O94985
Antibodypedia	CLSTN1 antibodies

PROTEIN BROWSER

CLSTN1-001	CLSTN1-002	CLSTN1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLSTN1-001 ENSP00000366513 ENST00000377298	O94985 [Direct mapping] Calsyntenin-1 Soluble Alc-alpha CTF1-alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001540 [beta-amyloid binding] GO:0001558 [regulation of cell growth] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0042988 [X11-like protein binding] GO:0045211 [postsynaptic membrane] GO:0050806 [positive regulation of synaptic transmission] GO:0051965 [positive regulation of synapse assembly] GO:0070062 [extracellular exosome] GO:0097481 [neuronal postsynaptic density] Show all	981 aa 109.8 kDa	Yes	1
CLSTN1-002 ENSP00000354997 ENST00000361311	O94985 [Direct mapping] Calsyntenin-1 Soluble Alc-alpha CTF1-alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001540 [beta-amyloid binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0042988 [X11-like protein binding] GO:0045211 [postsynaptic membrane] GO:0070062 [extracellular exosome] Show all	971 aa 108.6 kDa	Yes	1
CLSTN1-003 ENSP00000401934 ENST00000435891	Q5SR54 [Direct mapping] Calsyntenin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	782 aa 88 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.