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CLSTN1

GENERAL INFORMATION

Gene name

 CLSTN1

Gene description

 Calsyntenin 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues with distinct expression in the neurons.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA012412
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012412

GENE INFORMATION

Gene name

 CLSTN1 (HGNC Symbol)

Synonyms

 CDHR12, CSTN1, KIAA0911

Description

 Calsyntenin 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

 1

Cytoband

 p36.22

Chromosome location (bp)

 9729026 - 9824526

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171603 (version 83.38)

Entrez gene

 22883

UniProt

 O94985 (UniProt - Evidence at protein level)

neXtProt

 NX_O94985

Antibodypedia

 CLSTN1 antibodies

PROTEIN BROWSER
CLSTN1-001
CLSTN1-002
CLSTN1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLSTN1-001
ENSP00000366513
ENST00000377298
O94985 [Direct mapping]
Calsyntenin-1 Soluble Alc-alpha CTF1-alpha
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001540 [beta-amyloid binding]
GO:0001558 [regulation of cell growth]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019894 [kinesin binding]
GO:0030054 [cell junction]
GO:0042988 [X11-like protein binding]
GO:0045211 [postsynaptic membrane]
GO:0050806 [positive regulation of synaptic transmission]
GO:0051965 [positive regulation of synapse assembly]
GO:0070062 [extracellular exosome]
GO:0097481 [neuronal postsynaptic density]
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 981 aa
109.8 kDa 		Yes 1
CLSTN1-002
ENSP00000354997
ENST00000361311
O94985 [Direct mapping]
Calsyntenin-1 Soluble Alc-alpha CTF1-alpha
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001540 [beta-amyloid binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0019894 [kinesin binding]
GO:0030054 [cell junction]
GO:0042988 [X11-like protein binding]
GO:0045211 [postsynaptic membrane]
GO:0070062 [extracellular exosome]
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 971 aa
108.6 kDa 		Yes 1
CLSTN1-003
ENSP00000401934
ENST00000435891
Q5SR54 [Direct mapping]
Calsyntenin-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 782 aa
88 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.