Cell atlas - ANO5 - The Human Protein Atlas

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ANO5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ANO5
Gene description	Anoctamin 5
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HEK 293, A549)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, A549) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ANO5 (HGNC Symbol)
Synonyms	GDD1, LGMD2L, TMEM16E
Description	Anoctamin 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Chromosome	11
Cytoband	p14.3
Chromosome location (bp)	22193176 - 22283357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171714 (version 83.38)
Entrez gene	203859
UniProt	Q75V66 (UniProt - Evidence at protein level)
neXtProt	NX_Q75V66
Antibodypedia	ANO5 antibodies

PROTEIN BROWSER

ANO5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANO5-001 ENSP00000315371 ENST00000324559	Q75V66 [Direct mapping] Anoctamin-5 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006821 [chloride transport] GO:0016021 [integral component of membrane] GO:0031982 [vesicle] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	913 aa 107.2 kDa	No	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.